What is CoQ10? Can Shilajit Resin Boost CoQ10 efficiency?

What is CoQ10?

Also called by its full name coenzyme Q10, CoQ10 is a compound that occurs naturally within the cells of the human body. It is found in the mitochondria, rod-shaped structures inside each cell that serve as power generators for that cell. Coenzyme Q10 (CoQ10) is a natural antioxidant synthesized by the body, found in many foods, and available as a supplement. It comes in two forms: ubiquinol, the active antioxidant form, and ubiquinone, the oxidized form, which the body partially converts to ubiquinol. Many multi-ingredient supplements contain both forms of CoQ10. In general, coenzymes support enzymes in their various biochemical functions. CoQ10 is a vital participant in the chain of metabolic chemical reactions that generate energy within cells. It is found in every cell of the body (the name ubiquinone stems from its ubiquity), but is present in higher concentrations in organs with higher energy requirements such as the kidneys, liver, and heart.

What does CoQ10 do?

A. The main CoQ10 benefit involves its role in the creation of an important molecule known as adenosine triphosphate (ATP). ATP helps direct energy where it is needed within a cell and within the human body. As such, ATP is essential for healthy metabolism and is a key part of a number of processes within the body, such as the contraction of muscles.

Other possible CoQ10 benefits are being investigated. “It is also thought to function as an antioxidant along with vitamins E and C, and selenium,” says Roberta Anding, MS, RD, a clinical dietitian at Baylor College of Medicine and Texas Children’s Hospital in Houston, and a spokeswoman for the American Dietetic Association. “It is also suggested that there are diseases that may respond to CoQ10 supplementation.”

Does Shilajit resin boost CoQ10?

Shilajit resin can boost CoQ10 efficiency. Found in the Altai mountains, shilajit resin is prized for its ability to carry energy and nutrition into the body. When CoQ10 and shilajit are combined, scientists have discovered improved mitochondrial function, enhancement of the mitochondria’s ability to convert food into energy, and increased energy available to tissues.

The combination of CoQ10 and shilajit has been shown to result in elevated levels of the body’s primary source of energy: ATP (adenosine triphosphate). Shilajit plus CoQ10 enhances mitochondrial health, which is a vital factor in preventing aging and disease at the cellular level.

How does it work?

It’s simple. Shilajit restores and sustains cellular energy by enhancing the production of the body’s primary source of energy: adenosine triphosphate, or simply ATP. ATP is the usable energy that is formed when organelles called mitochondria convert energy from food. As people age, this conversion process becomes sluggish, resulting in a body-wide energy deficiency.

For centuries, practitioners of Ayurvedic medicine (one of the world’s oldest holistic healing systems) relied on a curious substance called shilajit to treat or prevent a host of health problems. Preserved in the rocks of the Altai mountains, shilajit is a rich organic material that forms in the part of the earth called the rhizosphere—the thin layer where living roots and microorganisms interact with the rocky core of the planet itself.

In traditional medicine, shilajit is prized for its ability to restore energy, increase fertility, enhance immunity, and safeguard memory against the effects of aging. Now, modern scientists have proven that this rare herbal tonic beneficially impacts cellular energy, diabetes, Alzheimer’s, and Parkinson’s disease, and that it can reduce inflammation, improve memory, protect against cognitive decline, and more.

As scientists further investigated the properties of shilajit, they determined that it is an adaptogen, which is a substance that helps the body adapt to internal and external stressors. In other words, shilajit is a natural stress-fighting, fatigue-busting substance that can not only help one feel revitalized, but can help rejuvenate tired cells. This can beneficially impact the entire body.

CoQ10 with Shilajit — Boosts Energy and Protects Mitochondria

Since shilajit’s components protect, preserve, and enhance CoQ10 in the laboratory, you might expect that putting shilajit and CoQ10 together in one supplement would have even greater effects in living organisms. And you would be right!
Compared to a placebo, CoQ10 with shilajit significantly increased energy production (ATP) by 144% in muscle, and the combination was 27% better than CoQ10 alone!A team of researchers published compelling results in 2009 showing how shilajit plus CoQ10 preserve and protect energy function in mice.15 The researchers engaged mice in strenuous and stressful physical activity for two hours each day for seven days. Starting on day four they supplemented the animals orally with CoQ10 alone, shilajit alone, or the two in combination. They measured levels of CoQ10, ATP, and other compounds vital in mitochondrial energy production. They then compared the results with those of the stressed animals given a placebo only, and with animals at rest. The outcomes were nothing short of astounding:

  • Compared to a placebo, CoQ10 + shilajit significantly increased energy production (ATP) by 56% in the brain, and the combination was 40% better than CoQ10 alone!
  • Compared to control animals at rest, CoQ10 levels in the intense exercise-stressed animals plummeted by 75% — yet the combination of CoQ10 + shilajit restored CoQ10 levels to within 15% of the normal rested animals’ levels!
  • The CoQ10 + shilajit combination produced similar synergistic effects on a variety of other measures of cellular energy status, especially in muscle and brain tissue.

Some health benefits that doctors believe people could get as a result of taking Shilajit resin:

  • Helping treat high blood pressure and heart disease
  • Enhancing immune system function
  • Providing an energy boost for people dealing with fatigue
  • Reducing high cholesterol levels in the blood
  • Stabilizing blood sugar levels of people with diabetes
  • Assisting in the treatment of cancer or the protection of organs from toxic chemotherapy drugs
  • Treating gum disease
  • Slowing down dementia progression
  • Increasing sperm count and motility
  • Preventing or treating migraine headaches

What are the signs of a Coenzyme Q10 deficiency?

Studies in both animals and humans have associated significantly decreased levels of CoQ10 with a wide variety of diseases. Since this enzyme is found in high concentration in heart muscle cells, deficiency has been associated with cardiovascular problems including angina, arrhythmia, heart failure and high blood pressure. Problems with blood sugar regulation, gingival (gum) health, and stomach ulcers have also been associated with CoQ10 deficiency. Those who are taking statins to lower cholesterol are at particular risk for deficiency, because not only do statins reduce cholesterol levels, but they also block CoQ10 synthesis in the body. Low CoQ10 levels in patients on statins can contribute to the common side effects of statin therapy such as fatigue and aching joints and muscles.


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References

  1. Duberley KE, Abramov AY, Chalasani A, et al. Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment. J Inherit Metab Dis. 2013 Jan;36(1):63-73.
  2. Fernández-Ayala DJ, López-Lluch G, García-Valdés M, et al. Specificity of coenzyme Q10 for a balanced function of respiratory chain and endogenous ubiquinone biosynthesis in human cells. Biochim Biophys Acta. 2005;1706:174-83.
  3. López-Martín JM, Salviati L, Trevisson E, et al. Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis. Hum Mol Genet. 2007;16:1091-7.
  4. Cordero MD, Cotán D, del-Pozo-Martín Y, et al. Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Nutrition. 2012 Nov-Dec;28(11-12):1200-3.
  5. Takahashi M, Ogawara M, Shimizu T, Shirasawa T. Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous coenzyme Q(10). Exp Gerontol. 2012 Mar;47(3):276-9.
  6. Ishii N, Senoo-Matsuda N, Miyake K, et al. Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech Ageing Dev. 2004 Jan;125(1):41-6.
  7. Janson M. Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging. Clin Interv Aging. 2006;1(3):261-5.
  8. Ochoa JJ, Quiles JL, Lopez-Frias M, et al. Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich diet. J Gerontol A Biol Sci Med Sci. 2007;62(11):1211-8.
  9. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20(35):5507-9.
  10. Bhattacharyya S, Pal D, Gupta AK, et al. Beneficial effect of processed shilajit on swimming exercise induced impaired energy status of mice. Pharmacologyonline. 2009;1:817-25.
  11. Available at: http://lifespa.com/ayurvedic-supplement-facts/shilajit/. Accessed October 22, 2015.
  12. Bhattacharyya S, Pal D, Banerjee D. Shilajit dibenzo—pyrones: mitochondria targeted antioxidants. Pharmacology online. 2009;2:690-8.
  13. Agarwal SP, Khanna R, Karmarkar R, et al. Shilajit: a review. Phytother Res. 2007 May;21(5):401-5.
  14. Bhattacharya SK, Bhattacharya A, Chakrabarti A. Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas . Indian J Exp Biol. 2000 Feb;38(2):119-28.
  15. Goel RK, Banerjee RS, Acharya SB. Antiulcerogenic and antiinflammatory studies with shilajit. J Ethnopharmacol.1990 Apr;29(1):95-103.
  16. Park JS, Kim GY, Han K. The spermatogenic and ovogenic effects of chronically administered Shilajit to rats. J Ethnopharmacol. 2006 Oct 11;107(3):349-53.
  17. Ghosal S. Shilajit in Perspective. Oxford, U.K.: Narosa Publishing House; 2006.
  18. Malekzadeh G, Dashti-Rahmatabadi MH, Zanbagh S, et al. Mumijo attenuates chemically induced inflammatory pain in mice. Altern Ther Health Med. 2015 Mar-Apr;21(2):42-7.
  19. De Pauw A, Tejerina S, Raes M, Keijer J, Arnould T. Mitochondrial (dys)function in 15. adipocyte (de)differentiation and systemic metabolic alterations. Am J Pathol. 2009 Sep;175(3):927-39.
  20. Conley KE, Amara CE, Jubrias SA, Marcinek DJ. Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo. Exp Physiol. 2007 Mar;92(2):333-9.
  21. Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial dysfunction in cardiac disease: ischemia—reperfusion, aging, and heart failure. J Mol Cell Cardiol. 2001 Jun;33(6):1065-89.
  22. Barja G. Free radicals and aging. Trends Neurosci. 2004 Oct;27(10):595-600.
  23. Hekimi S, Lapointe J, Wen Y. Taking a “good” look at free radicals in the aging process. Trends Cell Biol. 2011 Oct;21(10):569-76.
  24. Liochev SI. Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med. 2013 Jul;60:1-4.
  25. Sinha K, Das J, Pal PB, et al. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol. 2013 Jul;87(7):1157-80.
  26. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012 Jan;5(1):9-19.
  27. Wei YH, Lu CY, Lee HC, et al. Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Ann NY Acad Sci. 1998 Nov 20;854:155-70.
  28. Mandavilli BS, Santos JH, Van Houten B. Mitochondrial DNA repair and aging. Mutat Res. 2002 Nov 30;509(1-2):127-51.
  29. Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000 Aug;29(3-4):222-30.
  30. Wei YH, Lee HC. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging.Exp Biol Med (Maywood). 2002 Oct;227(9):671-82.
  31. Hamilton ML, Van Remmen H, Drake JA, et al. Does oxidative damage to DNA increase with age? PNAS. 2001;98(18):10469-74.
  32. Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 1989;1(8639):642-5.
  33. Rolo AP, Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol. 2006 Apr 15;212(2):167-78.
  34. Picard M, Turnbull DM. Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging.Diabetes. 2013 Mar;62(3):672-8.
  35. Scheffler K, Krohn M, Dunkelmann T, et al. Mitochondrial DNA polymorphisms specifically modify cerebral—amyloid proteostasis. Acta Neuropathol. 2012 Aug;124(2):199-208.
  36. Maruszak A, Zekanowski C. Mitochondrial dysfunction and Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):320-30.
  37. Lanza IR, Nair KS. Mitochondrial function as a determinant of life span. Pflugers Arch. 2010 Jan;459(2):277-89.
  38. Robb EL, Page MM, Stuart JA. Mitochondria, cellular stress resistance, somatic cell depletion and lifespan. Curr Aging Sci. 2009 Mar;2(1):12-27.
  39. Alexeyev MF, LeDoux SP, Wilson GL. Mitochondrial DNA and aging. Clin Sci (Lond). 2004 Oct;107(4):355-64.
  40. Quiles JL, Ochoa JJ, Huertas JR, Mataix J. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet. Exp Gerontol. 2004 Feb;39(2):189-94.
  41. Available at: http://www.cdc.gov/nchs/fastats/life-expectancy.htm. Accessed September 9, 2015.
  42. Sander S, Coleman CI, Patel AA, et al. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail. 2006 Aug;12(6):464-72.
  43. Dai YL, Luk TH, Yiu KH, et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial.Atherosclerosis. 2011 Jun;216(2):395-401.
  44. Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6.
  45. Mortensen SA, et al. Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React. 1990;12(3):155-62.
  46. Sohal RS, Forster MJ. Coenzyme Q, oxidative stress and aging. Mitochondrion. 2007 Jun;7 Suppl:S103-11.
  47. Karbowski M, Neutzner A. Neurodegeneration as a consequence of failed mitochondrial maintenance. Acta Neuropathol. 2012 Feb;123(2):157-71.
  48. Lenaz G, Bovina C, D’Aurelio M, et al. Role of mitochondria in oxidative stress and aging. Ann N Y Acad Sci. 2002 Apr;959:199-213.
  49. Aminul I, Runa G, Dipankar B, et al. Biotransformation of 3-hydroxydibenzo—pyrone into 3,8 dihydroxydibenzo—pyrone and aminoacyl conjugates by Aspergillus niger isolated from native shilajit. Electron J Biotechnol.2008;11(3).
  50. Surapaneni DK, Adapa SR, Preeti K, Teja GR, Veeraragavan M, Krishnamurthy S. Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats. J Ethnopharmacol. 2012 Aug 30;143(1):91-9.
  51. Visser SA. Effect of humic substances on mitochondrial respiration and oxidative phosphorylation. Sci Total Environ.1987 Apr;62:347-54.
  52. Klapper L, McKnight DM, Fulton JR, et al. Fulvic acid oxidation state detection using fluorescence spectroscopy.Environ Sci Technol. 2002 Jul 15;36(14):3170-5.
  53. Royer RA, Burgos WD, Fisher AS, et al. Enhancement of biological reduction of hematite by electron shuttling and Fe(II) complexation. Environ Sci Technol. 2002 May 1;36(9):1939-46.
  54. Kang SH, Choi W. Oxidative degradation of organic compounds using zero-valent iron in the presence of natural organic matter serving as an electron shuttle. Environ Sci Technol. 2009 Feb 1;43(3):878-83.
  55. Dantas JM, Kokhan O, Pokkuluri PR, Salgueiro CA. Molecular interaction studies revealed the bifunctional behavior of triheme cytochrome PpcA from Geobacter sulfurreducens toward the redox active analog of humic substances.Biochim Biophys Acta. 2015 Jun 9;1847(10):1129-38.
  56. Fernandez-Moriano C, Gonzalez-Burgos E, Gomez-Serranillos MP. Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases. Oxid Med Cell Longev. 2015;2015:408927.
  57. Hroudova J, Singh N, Fisar Z. Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer’s disease. Biomed Res Int. 2014;2014:175062.
  58. Picone P, Nuzzo D, Caruana L, Scafidi V, Di Carlo M. Mitochondrial dysfunction: different routes to Alzheimer’s disease therapy. Oxid Med Cell Longev. 2014;2014:780179.
  59. Schliebs R, Liebmann A, Bhattacharya SK, et al. Systemic administration of defined extracts from Withania somnifera (Indian Ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain. Neurochem Int. 1997 Feb;30(2):181-90.
  60. Guzman-Martinez L, Farias GA, Maccioni RB. Tau oligomers as potential targets for Alzheimer’s diagnosis and novel drugs. Front Neurol. 2013;4:167.
  61. Cornejo A, Jimenez JM, Caballero L, Melo F, Maccioni RB. Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer’s disease. J Alzheimers Dis. 2011;27(1):143-53.
  62. Jaiswal A K, Bhattacharya S K. Effects of Shilajit on memory, anxiety and brain monoamines in rats. Indian J Pharmacol 1992;24(1):12-7.
  63. Gaikwad NS, Panat AV, Deshpande MS, Ramya K, Khalid PU, Augustine P. Effect of shilajit on the heart of Daphnia: A preliminary study. J Ayurveda Integr Med. 2012 Jan;3(1):3-5.
  64. Kaur S, Kumar P, Kumar D, Kharya MD, Singh N. Parasympathomimetic effect of shilajit accounts for relaxation of rat corpus cavernosum. Am J Mens Health. 2013 Mar;7(2):119-27.
  65. Joukar S, Najafipour H, Dabiri S, Sheibani M, Sharokhi N. Cardioprotective effect of mumie (shilajit) on experimentally induced myocardial injury. Cardiovasc Toxicol. 2014 Sep;14(3):214-21.
  66. Hagen TM, Ingersoll RT, Lykkesfeldt J, et al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999 Feb;13(2):411-8.
  67. DiMauro S, Tanji K, Bonilla E, Pallotti F, Schon EA. Mitochondrial abnormalities in muscle and other aging cells: classification, causes, and effects. Muscle Nerve. 2002 Nov;26(5):597-607.
  68. Choksi KB, Nuss JE, Boylston WH, Rabek JP, Papaconstantinou J. Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes. Free Radic Biol Med. 2007 Nov 15;43(10):1423-38.
  69. Sullivan PG, Brown MR. Mitochondrial aging and dysfunction in Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):407-10.
  70. Rosenfeldt FL, Pepe S, Ou R, et al. Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. Biofactors. 1999;9(2-4):291-9.
  71. Kalen A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids. 1989;24(7):579-84.
  72. Hoppe U, Bergemann J, Diembeck W, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2-4):371-8.